GLP-1 medications are a group of prescription drugs that help improve blood sugar control and may also promote weight loss. These medications, known as glucagon-like peptide-1 (GLP-1) agonists, work by mimicking a hormone that regulates blood sugar and appetite. Weight loss results can vary based on the specific GLP-1 drug and dosage. Research shows that individuals using Semaglutide, alongside making lifestyle changes, lost an average of 33.7 pounds (15.3 kg), compared to just 5.7 pounds (2.6 kg) for those not using the medication. Typically, GLP-1 medications like Semaglutide are administered through a weekly injection.
Common Side Effects:
Nausea
Vomiting
Diarrhea
These side effects can often be reduced by gradually increasing the dosage as recommended by your healthcare provider. Ensuring you follow the prescribed dosage plan is key to minimizing the risk and severity of side effects. In some cases, anti-nausea medications, such as ondansetron (generic Zofran), can help alleviate symptoms of nausea.
Important Considerations:
One of the more serious risks associated with GLP-1 medications is low blood sugar (hypoglycemia). However, this risk is typically higher if you are also taking other medications, such as sulfonylureas or insulin, that lower blood sugar. If you are prescribed a GLP-1 medication, your healthcare provider will monitor your treatment closely to minimize these risks.
GLP-1 drugs are not recommended for individuals with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia. Lab studies have shown a potential link between these medications and thyroid tumors in rodents. However, the risk to humans is not yet fully understood, as more long-term research is needed. Additionally, GLP-1 medications are not suitable for individuals with a history of pancreatitis.
Be sure to discuss any concerns or pre-existing conditions with your healthcare provider to determine if GLP-1 medications are right for you.
References: https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/byetta/faq-20057955